Effects of Oral Iron Supplements in Pregnancy with IDA in Association with Oxidative Stress
DOI:
https://doi.org/10.32413/pjph.v14iSpecial.ni.1367Keywords:
IDA, oxidative stress, maternal anemiaAbstract
Background: Iron deficiency anemia (IDA) is associated with adverse outcomes related to hemoglobin (Hb) and red cell indices and is now recognized as a major contributor to oxidative stress (OS). Maternal IDA during pregnancy is one of the most common nutritional deficiencies worldwide, exposing both the mother and developing fetus to the risk of OS. This study aims to identify the effects of IDA and oral iron supplements on oxidative stress during pregnancy.
Methodology: The IDA group comprised 90 pregnant women between 16 to 20 weeks of gestation. The study lasted 12 weeks with follow-up visits every 4 weeks. Two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were studied as OS parameters. Hemoglobin (Hb), serum ferritin concentration (SFC), and total iron binding capacity (TIBC) were also measured.
Results: The study found decreased levels of SOD, Hb, and SFC in the anemic group, which showed significant improvement after iron supplementation. GSH-Px and TIBC values were significantly lower compared to the control group. There was a direct relationship between SOD and Hb levels, with the highest SOD levels observed in conjunction with the highest Hb values.
Conclusion: Oral iron administration to treat IDA during pregnancy not only improves hematological parameters but also decreases oxidative stress by improving SOD levels. However, other micronutrient deficiencies might be responsible for the alterations in GSH-Px levels.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Shamaila Khalid, Dabeeran Zehra, Aisha Abdul Haq, Syeda Sana Ahmed, Hafiz Syed Imran-ul- Haq
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.