Effects of Oral Iron Supplements in Pregnancy with IDA in Association with Oxidative Stress

Authors

  • Shamaila Khalid Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Dabeeran Zehra Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Aisha Abdul Haq Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Syeda Sana Ahmed Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Hafiz Syed Imran-ul- Haq Dow International Medical College, Dow University of Health Sciences

DOI:

https://doi.org/10.32413/pjph.v14iSpecial.ni.1367

Keywords:

IDA, oxidative stress, maternal anemia

Abstract

Background: Iron deficiency anemia (IDA) is associated with adverse outcomes related to hemoglobin (Hb) and red cell indices and is now recognized as a major contributor to oxidative stress (OS). Maternal IDA during pregnancy is one of the most common nutritional deficiencies worldwide, exposing both the mother and developing fetus to the risk of OS. This study aims to identify the effects of IDA and oral iron supplements on oxidative stress during pregnancy.

 Methodology: The IDA group comprised 90 pregnant women between 16 to 20 weeks of gestation. The study lasted 12 weeks with follow-up visits every 4 weeks. Two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were studied as OS parameters. Hemoglobin (Hb), serum ferritin concentration (SFC), and total iron binding capacity (TIBC) were also measured.

 Results: The study found decreased levels of SOD, Hb, and SFC in the anemic group, which showed significant improvement after iron supplementation. GSH-Px and TIBC values were significantly lower compared to the control group. There was a direct relationship between SOD and Hb levels, with the highest SOD levels observed in conjunction with the highest Hb values.

 Conclusion: Oral iron administration to treat IDA during pregnancy not only improves hematological parameters but also decreases oxidative stress by improving SOD levels. However, other micronutrient deficiencies might be responsible for the alterations in GSH-Px levels.

Downloads

Published

05-08-2024

How to Cite

1.
Khalid S, Zehra D, Haq AA, Ahmed SS, Haq HSI- ul-. Effects of Oral Iron Supplements in Pregnancy with IDA in Association with Oxidative Stress. Pak J Public Health [Internet]. 2024 Aug. 5 [cited 2024 Nov. 8];14(Special.NI):134-8. Available from: https://pjph.org/pjph/article/view/1367