Comparison Between Diagnostic Accuracy of MR Cerebral Perfusion and Histopathology for Diagnosing Low and HighGrade Gliomas

Authors

  • Aisha Hameed Federal Government PGMI, Islamabad
  • Syed Hassan Shafqat PIMS
  • Sania Hameed
  • Safina Hameed
  • Javed Anwar AFIRI, MH, Rawalpindi
  • Fahd Shah FGH

DOI:

https://doi.org/10.32413/pjph.v13i4.1239

Keywords:

Brain tumors, diagnostic criteria, radiology, low-middle income country

Abstract

Background: Gliomas represent the most prevalent type of primary brain tumor and are associated with a significant mortality rate. The utilization of MR cerebral perfusion proves effective in distinguishing between low-grade and high-grade gliomas, surpassing the capabilities of routine MRI. This distinction allows for the timely initiation of surgical intervention. We aimed to document the diagnostic accuracy of MR cerebral perfusion against the gold standard of lab-based histopathology.

Methods: We conducted this cross-sectional validation study over a duration of six months in the outpatient radiology department of a major public sector hospital of Rawalpindi, Pakistan. All patients had MR cerebral perfusion Scan of brain in order to differentiate low grade and high grade glioma. Quantitative rCBV analysis was carried out adopting a threshold value of 3, above this value the lesion was considered at a high grade. The results were written on specially designed proforma.

Results: A total 230 patients were included in the study with mean age of 50.68+16.36 and there were 135 (58.7%) male and 95 (41.3%) were female. There were 122 (53.0%) patients presented with low grade glioma and 108 (47.0%) patients presented with high grade glioma. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of MR cerebral perfusion to differentiate between low grade and high grade gliomas was 85.71%, 70.97%, 88.89%, 64.71% and 81.74% respectively.

Conclusion: This study concludes that the MR perfusion reliably identifies higher-grade features in a tumor that otherwise may not appear on standard MRI scan.

Author Biography

  • Aisha Hameed, Federal Government PGMI, Islamabad

    Associate Radiologist, Federal Government PGMI, Islamabad

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Published

28-12-2023

How to Cite

1.
Hameed A, Shafqat SH, Hameed S, Hameed S, Anwar J, Shah F. Comparison Between Diagnostic Accuracy of MR Cerebral Perfusion and Histopathology for Diagnosing Low and HighGrade Gliomas. Pak J Public Health [Internet]. 2023 Dec. 28 [cited 2024 Jun. 14];13(4):172-5. Available from: https://pjph.org/pjph/article/view/1239